INFORMAZIONI SU
MUZZIN Samanta
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Supervisore:Dr.ssa Spessotto The role of EMILIN-1 in the development and progression of gastric cancer: mechanisms and strategies from a microenvironment perspective |
| Gastric cancer is an aggressive malignancy of the digestive system and a major health challenge worldwide. The aggressiveness of this disease is closely linked to the tumor microenvironment, which plays a crucial role in the development, progression, and metastasis of gastric cancer. Despite advances, several critical issues remain unresolved in gastric cancer research, particularly concerning the complex interactions between cellular and extracellular components within the tumor microenvironment. EMILIN-1, an extracellular matrix glycoprotein with known antiproliferative properties in skin and colon cancers, has shown promising potential. Preliminary data indicated that EMILIN-1 deposition is gradually lost during the progression of gastric lesions, suggesting a protective role of this protein in the early stages of gastric cancer. The aim of our project is to clarify the role of EMILIN-1 in the development and progression of gastric cancer, focusing on the mechanisms played by cellular components that regulate its expression and stability. |
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