INFORMAZIONI SU
PIVETTA Matteo
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Supervisori:Prof. Pucillo and Prof.ssa Frossi Exploring the molecular profile of B cells and its relationship with gut microbiome under physiological and pathological conditions |
| The immune system is an articulated structure composed of different cells, tissues, and organs that plays a crucial role in defending the organism against infections and counteracting the development of pathologies. In recent years, a close cross-talk between the immune system and the gut microbiome has been established, highlighting how the metabolites produced by different microbial populations can modulate the differential state of the immune system components, as well as their responses. Among all the cells of the immune system, B lymphocytes are a multifactorial cornerstone: their unique function is to produce antibodies, but in addition B cells can also present the antigen to other cells and produce pro- and anti-inflammatory cytokines depending on the microenvironmental conditions. My project aims to characterize the molecular and metabolic pathways that define B cells and their relationships with gut microbiota in different disease contexts (such as colorectal cancer and multiple sclerosis), with particular focus on the role of microbial Short-Chain Fatty Acids (SCFA) metabolites. Understanding the molecular correlations of B cells profile and microbiome composition could provide new perspectives on the role played by the cross-talk between the gut microbiome and the immune system in these diseases, as well as understanding the health status of patients and their response to treatments. Furthermore, the characterization of the B cell profile would help to define a more personalized medicine approach to modulate their differential state and metabolism, to provide a better quality of life to the patients. | |