INFORMAZIONI SU

UZAIR Ali

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Supervisore: Prof.ssa Colitti

Transcriptional Networks in Adipogenic and Thermogenic programming

To explore the molecular mechanism and signalling pathways involved in thermogenesis and adipogenesis using Simpson Golabi Behmel Syndrome (SGBS) cell strain. In humans there are two types of adipose tissues. White adipose tissue (WAT) that is formed by the accumulation of large lipid-accumulating adipocytes with fewer mitochondria. Unlike WAT, brown adipose tissue (BAT) is characterized by the presence of smaller multilocular lipid droplets with higher number of smaller mitochondria. The most important function of BAT is to maintain body temperature via adaptive thermogenesis by uncoupling the oxidation of energy substrates to ATP synthesis, releasing energy in form of heat. This process is dependent on uncoupling protein 1 (UCP1). Using RNA-seq we aim to study SGBS cells at different stages of differentiation and to study the browning effects of allicin, an organosulfur compound obtained from garlic.