INFORMAZIONI SU
MINISINI Martina
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Supervisore: Prof. Brancolini Class IIa HDACs as therapeutic targets in human diseases: new roles and new selective inhibitors |
| Epigenetic machinery involves several proteins which work alone or in complexes for the regulation of chromatin status. The dysregulation of these mechanisms can lead to disease development and cancer. The PhD project aims to understand the role of epigenetic complexes in the regulation of gene expression and cancer aggressiveness. These studies have important implications for the development of new therapeutic approaches for cancer treatment. The focus is on the epigenetic complex constituted by the class IIa family of HDACs and MEF2 transcription factors. The contribution of the complex to chromatin landscape, tumor microenvironment and the possibility of its targeting has been investigated. A particular emphasis was addressed to define correlations with the immune infiltrates and the immunomodulatory role of class IIa HDACs. In this regard the evaluation of CHD4, a chromatin regulator part of NuRD complex, was also investigated mainly in respect to the biology of regulatory T cells. | |