INFORMAZIONI SU
RANZINO Liliana
 |
Supervisore: prof. Brancolini The epigenetic network under class IIa HDACs supervision |
| Cellular senescence is a complex biological response characterized by highly stable cell cycle arrest and a deep epigenetic reprogramming. This widespread epigenetic resetting represents a pro survival response to an irreparable DNA damage and a permanent cell-cycle arrest. On the other hand, it also leads to a genomic reorganization promoting the transcription of pro-inflammatory genes. It is known the key role of the alterations in the H3K27ac/H3K27me3 ratio during premature senescence. The acetylation status of H3K27 during senescence is regulated by HDAC4. The research project has investigated, in HDAC4 knock-out (KO) cells entering premature senescence, the genomic regions undergoing H3K27me3 demethylation. This downregulation promoted endogenous retroviruses (ERVs) expression. ERVs can contribute to the creation of the proinflammatory senescence microenvironment. With our work, we aim to better understand the role played by ERVs deregulation during senescence. | |