INFORMAZIONI SU
SARDAR Alam
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Supervisori: Dr.ssa Spessetto e Dr.ssa Schiappacassi SGK2 and EMT: A new axis in Epithelial ovarian cancer? |
| Epithelial Ovarian Cancer (EOC) is the most lethal gynaecological malignancy due to the advanced stage at diagnosis and the development of drug-resistant recurrences. Our lab recently identified SGK2 (Serum-and Glucocorticoid-inducible kinase 2), a protein belonging to the AGC kinase family, as a novel modulator of platinum (PT) sensitivity in EOC, through the regulation of autophagy. Our lab performed proteomics on SGK2 overexpressing cells and some molecules which belong to EMT were enriched in SGK2 overexpressing cells. So, I am investigating a possible link between SGK2 and EMT molecules especially related to the cell’s junctions. Further I will assess the role of SGK2 in EOC cell growth and dissemination in-vitro as well as in-vivo. I will use CRISPR/Cas9 technology to generate SGK2 knock out and different SGK2 kinase mutants cells. I will investigate if SGK2 kinase activity is specifically involved in the migration of EOC cells. Further investigation could allow the identification of new actionable or druggable molecules/pathways. | |