INFORMAZIONI SU

MALAVASI Eleonora

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Supervisori: Prof. Brancolini e Prof.ssa Gagliano

Development of novel anti-neoplastic approaches to reduce the impact of mutagenic-carcinogenic chemotherapeutics in the environment

Chemotherapeutics currently used in clinical practice, are mutagenic agents responsible for environmental contaminations. Therefore, it is important to find alternative molecules with antineoplastic effects that are environmentally friendly to reduce the negative impact that the current ones have on the environment. Colorectal cancer (CRC) is the fourth most common cancer-related death and the third most common cancer. Considering its high diffusion in the population, the study of novel chemotherapeutics for CRC treatment will have a great impact on environmental implications. The project aims to develop novel compounds for anti-neoplastic therapy with reduced environmental impact, which are characterized by an absence/reduced DNA damage activity. For this purpose we will perform experiments on cell lines and human derived CRC organoids. Different compounds will be screened and selected for their cytotoxic action in the absence of DNA damage.