Objective The aim is to investigate the combined effects of hypoxia and sustained recumbency (bedrest), on human physiological systems. The partial pressure of oxygen in the environmental gas inside future planetary habitats will be lower than in atmospheric air. Prolonged exposure to low gravity will result in deconditioning of vital physiological systems, and may consequently constitute a threat to the health of the astronauts. However, it is unknown how prolonged exposure to both reduced gravity and hypoxia will affect health. The new knowledge has also implications for society in general, since chronic hypoxia and bedrest constitutes a model of the basic conditions experienced by patients suffering from respiratory insufficiency restricting them to a physically inactive life style. The challenge of the project lies in the complexity of the experimental interventions where healthy humans are confined to a hypoxic environment during prolonged bedrest. A series of studies will be conducted at the Planica hypoxia facility capable of housing 20 subjects at any simulated altitude. Subjects will remain in horizontal position (bedrest) or be ambulatory, but confined to the facility (ambulation) for 21 days/trial. Each subject will participate in three trials: hypoxic bedrest (simulated altitude 4000m), normoxic bedrest, and hypoxic ambulation. The effects will be investigated in experiments concerning metabolic, cardiorespiratory, musculoskeletal, haematological, immunological and thermoregulatory functions. In addition to the specific objectives, the study will be explorative in the sense that it will collect a broad spectrum of basic data corresponding to that obtained when 21-day bedrest experiments are conducted by ESA/NASA (bedrest core data). Thus, data from the experiments can readily be compared with core data from previous bedrest studies, and hence the added effects of hypoxia should be evident. Programme(s) FP7-SPACE - Specific Programme "Cooperation": Space Topic(s) SPA.2011.2.1-02 - Research and development for space exploration Call for proposal FP7-SPACE-2011-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator INSTITUT JOZEF STEFAN EU contribution € 303 955,00 Address Jamova 39 1000 Ljubljana Slovenia See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Research Organisations Administrative Contact Igor Kovac (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all KUNGLIGA TEKNISKA HOEGSKOLAN Sweden EU contribution € 284 895,74 Address BRINELLVAGEN 8 100 44 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Ola Eiken (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES ZENTRUM FUR LUFT - UND RAUMFAHRT EV Germany EU contribution € 164 539,50 Address LINDER HOHE 51147 Koln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Maximo Casas (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI UDINE Italy EU contribution € 203 064,75 Address VIA PALLADIO 8 33100 Udine See on map Region Nord-Est Friuli-Venezia Giulia Udine Activity type Higher or Secondary Education Establishments Administrative Contact Bruno Grassi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data POLITECNICO DI MILANO Italy EU contribution € 202 566,95 Address PIAZZA LEONARDO DA VINCI 32 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Andrea Aliverti (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution € 234 775,82 Address University Park NG7 2RD Nottingham See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Administrative Contact Paul Cartledge (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TRIESTE Italy EU contribution € 204 518,69 Address PIAZZALE EUROPA 1 34127 Trieste See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Higher or Secondary Education Establishments Administrative Contact Gianni Biolo (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 281 659,55 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Alexander Choukèr (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Participation ended Germany EU contribution No data Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data