The main project objective is to enhance accessibility, connectivity and competitiveness of alpine territories interested by Major Transport Infrastructures (MTIs) granting, at transnational level, a balanced and polycentric local development. This overall project objective is target through the implementation of local development models able to take advantage of the opportunities offered by the infrastructure in all phases of its life-cycle: design of the infrastructural project, implementation during its building and management, once the infrastructure is functioning.. The project starts from data collection to define a shared cognitive framework of the territorial resources, values and risks related to the MTI impacting on the partnership area. Then the intervention logic provides transnational solutions, with the provision of specific toolkits, to common problems and the implementation of pilot actions to test the toolkits proposed for local polycentric development. The last step is the evaluation of the efficacy of the toolkits developed and their generalization and transfer to decision makers at the European, National, Regional and local level.