A high number of treatments against various grape diseases characterizes vineyard management in Friuli Venezia Giulia. It is mandatory to introduce eco-sustainable management practices for the vine that, on the one hand, could ensure adequate levels of protection and maintain economically viable production, and on the other could reduce the impact on the environment and operators’ health. The proposed solutions involve the use of vine varieties resistant to powdery mildew and downy mildew, integrated by the use of treatments with low environmental impact, to obtain at least a partial substitution of conventional treatments. In addition, the use of bio-agents obtained from plant extracts or containing peroxides, is suggested. The use of these innovative products would guarantee the ability to counteract pathogens even near grape harvesting stage, in full compliance with shortage times and with residue absence in grapes. This strategy will have a considerable relevance on reducing the environmental impact on the vineyard ecosystem and the reduction of hazardous residues in wine, protecting the health of employers and consumers. It could also be evaluated the economic benefits deriving from a better visibility and appreciation of the product by consumers, who are increasingly aware of the environmental issues and wine healthiness. This project has passed the first evaluation phase and received an initial funding of € 25,000 provided by the European Union, in the framework of the PSR (Piano di Sviluppo Rurale), action 16.1.1. This action concerns the establishment of operative groups as implementation of the European Innovation Plan on productivity and sustainability in agriculture.