INFORMAZIONI SU
STEFENATTI Linda
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Supervisori: Dr.ssa Spessotto e Dr. Baldassare Non-mutational mechanism of Platinum resistance in ovarian cancer |
| Ovarian cancer is the eight most common malignancies in women worldwide. First line therapy combines surgery with platinum-based chemotherapy. Despite the initial response, progressive develop of drug resistance becomes more frequent and difficult to avoid. Overcoming Pt- resistance is one of the main unmet clinical needs for EOC patient. In particular we will investigate the role of USP1, a deubiquitinase protein that regulates processes in response to DNA damage repair and Epithelial to Mesenchymal transition, already identified as one of the proteins possibly involved in PT-resistance. Thus, the aim of my PhD project is to investigate the role of USP1 in Platinum response and resistance, identifying new possible therapies to overcome EOC patients recurrences. For this instance, we will explore the transcriptional, translational and post- translational regulation of USP1, comparing its normal activity with our Pt res cell models, trying to identify new possible mechanism involved in platinum resistance. |
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